Парацетамол и похмелье: опасная комбинация?

Ацетаминофен вреден для печени, если вы принимаете его слишком много. То же самое касается алкоголя. Так стоит ли воздерживаться от использования парацетамола для облегчения похмелья на следующее утро? Наверное, да, хотя биология взаимодействия этих двух веществ сложнее, чем вы думаете. Больше источников Medline Plus: Trusted Health Information for You. Acetaminophen. U.S. National Library of Medicine, National Institute of Health. AHFS Consumer Medication Information. Revised: 15 August 2013. Accessed online: 27 September 2013. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html FDA information on acetaminophen toxicity: http://www.fda.gov/Drugs/DrugSafety/SafeUseInitiative/ucm230396.htm Mayo Clinic: Acetaminophen and Children: Why Dose Matters: http://www.mayoclinic.com/health/acetaminophen/HO00002 Pro Publica report on acetaminophen risks: http://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed L.E. Schmidt, K Dalhoff, H.E. Poulson. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology (32) 2002; p.876-882. http://www.ncbi.nlm.nih.gov/pubmed/11915034 F. Yang, D. A. Beard. Thermodynamically based profiling of drug metabolism and drug-drug metabolic interactions: A case study of acetaminophen and ethanol toxic interactions. Biophysical Chemistry, 120 (2) p. 121-134. 20 March 2006. Accessed online: 27 September 2013. http://dx.doi.org/10.1016/j.bpc.2005.10.013 P. Zhao, T.K. Kalhourn, J.T. Slattery. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rats. Hepatology (36); p. 326-335. 2002. K. Thummel, et al. Ethanol and production of hepatotoxic metabolite of acetaminophen in healthy adults. Clinical Pharmacology and Therapeutics (2000) 67; p. 591-599. http://dx.doi.org/10.1067/mcp.2000.106574 КОМАНДА RISK BITES НА ЭТОЙ НЕДЕЛЕ: Продюсер: Andrew Maynard Директор по исследованиям: David Faulkner Фоновые исследования: Alyssa berry Risk Bites помогает понять риски. Мы расскажем обо всем: от понимания и взвешивания рисков и преимуществ повседневных продуктов до общих научных исследований в области здравоохранения, потенциального влияния новых технологий и важности рисков. Если вам нравятся наши видео, подпишитесь на наш канал и поделитесь им! Перевод и редаб: alugha Жми сюда, тут больше видеороликов: https://alugha.com/RiskBites

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