Paracetamol und Kater: Eine gefährliche Kombination?
Paracetamol ist schlecht für die Leber, wenn man zu viel davon nimmt. Das Gleiche gilt für Alkohol. Sollte man also darauf verzichten mit Paracetamol den Kater am Morgen danach zu lindern? Wahrscheinlich ja - obwohl die Biologie der Wechselwirkung beider Substanzen komplexer ist, als man vielleicht denkt.
Weitere Quellen
Medline Plus: Trusted Health Information for You. Acetaminophen. U.S. National Library of Medicine, National Institute of Health. AHFS Consumer Medication Information. Revised: 15 August 2013. Accessed online: 27 September 2013. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html
FDA information on acetaminophen toxicity: http://www.fda.gov/Drugs/DrugSafety/SafeUseInitiative/ucm230396.htm
Mayo Clinic: Acetaminophen and Children: Why Dose Matters: http://www.mayoclinic.com/health/acetaminophen/HO00002
Pro Publica report on acetaminophen risks: http://www.propublica.org/article/tylenol-mcneil-fda-use-only-as-directed
L.E. Schmidt, K Dalhoff, H.E. Poulson. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology (32) 2002; p.876-882. http://www.ncbi.nlm.nih.gov/pubmed/11915034
F. Yang, D. A. Beard. Thermodynamically based profiling of drug metabolism and drug-drug metabolic interactions: A case study of acetaminophen and ethanol toxic interactions. Biophysical Chemistry, 120 (2) p. 121-134. 20 March 2006. Accessed online: 27 September 2013. http://dx.doi.org/10.1016/j.bpc.2005.10.013
P. Zhao, T.K. Kalhourn, J.T. Slattery. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rats. Hepatology (36); p. 326-335. 2002.
K. Thummel, et al. Ethanol and production of hepatotoxic metabolite of acetaminophen in healthy adults. Clinical Pharmacology and Therapeutics (2000) 67; p. 591-599. http://dx.doi.org/10.1067/mcp.2000.106574
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