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The gut microbiome has a significant influence on various diseases ranging from malnutrition to chronic inflammation. It is largely shaped by environmental factors, like diet and lifestyle. How the genetics of the individual affect the composition of the microbiome, however, was largely unknown.
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RUTH LEY explains in this video that the research team addressed this question by comparing the microbiome of over 1000 twin pairs based on DNA extracted from their stool samples. These comparisons allowed the researchers to compile a list of heritable microbes, top of which is a family of bacteria called the Christensenellaceae.
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One key finding was that the microbiome of lean individuals contains more of this type of bacteria as compared to the microbiome of obese people. Further experiments showed that, if Christensenellaceae are given to germ-free mice, their amount of body fat is reduced. These results might lead to novel therapeutic approaches to obesity and associated diseases.
Who is Ruth Ley?
https://www.mpg.de/9751550/entwicklungsbiologie_ley
This LT Publication is divided into the following chapters:
0:00 Question
1:14 Method
3:03 Findings
6:41 Relevance
7:49 Outlook
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Vinyl or analog records have experienced a tremendous upsurge in popularity over the last decade. In this video, DOMINIK BARTMANSKI analyzes the reasons underlying vinyl’s resurgence in an age where digital music seemed destined to wipe it out.
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It has been heretofore understood that patterns of cloudiness are controlled by large scale weather systems. In this video, BJORN STEVENS challenges this orthodoxy, arguing that small and intermediate scales of motion play a key role in determining the Eart
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Massive algae blooms appear in spring in certain bodies of water only to vanish within a number of weeks. In this video, BERNHARD M. FUCHS analyzes the degradation of such algae, exploring which organisms are involved and what they actually do.
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